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Games of life and death: antibiotic resistance and production through the lens of evolutionary game theory

Partners' Institution
University of Perugia
Reference
CONLIN P. L., CHANDLER, J. R. & KERR, B. 2014. Games of life and death: antibiotic resistance and production through the lens of evolutionary game theory. Curr Opin Microbiol, 21, 35-44.
Thematic Area
Chemistry/Biology
DOI
10.1016/j.mib.2014.09.004
Summary
This review is used to demonstrate how game theory can be a useful first step in modeling and understanding interactions among bacteria that produce and resist antibiotics. At first the basic features of evolutionary game theory are introduced leading to the exploration of model microbial systems that correspond to some classical games. Each game taken as example describes a different category of social interaction with different resulting population dynamics. Finally, the game theoretical perspective is used to guide the researchers expectations about the evolution of some forms of antibiotic resistance and production.
Relevance for Complex Systems Knowledge
The publication demonstrates how a mathematical framework such that of the game theory, is particularly helpful in understanding evolutionary outcomes in circumstances where antibiotic resistance and production involve a social dimension.
Point of Strength
In this review the researchers focus on the antibiotic resistance seen as a product of social interaction as opposed to the more studied perspective of an asocial event.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License