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Aspirin screen experiment

Area
Natural Sciences
Thematic Area
Applied Chemistry, Green and sustainable Chemistry
Description of the Interactive Tool
The Aspirin Screen Experiment by Royal Society of Chemistry is an interactive tool relative to the synthesis of acetylsalicylic acid and it is developed in 4 levels:
• 1st level: Historical information concerning the production of aspirin, information relative to synthesis of acetylsalicylic acid, mechanism of reaction, set up of apparatus for the synthesis, calculations.
• 2nd level: Properties of acetylsalicylic acid, purification and TLC chromatography
• 3rd level: Reaction conditions (temperature, reaction time, catalysts).
• 4th level: Alternative synthetic routes with different reagents, TLC to identify which reagent produces acetylsalicylic acid and choice of the best route for industrial scale with concern to the environment impact.
Points of Strength
These interactive videos gradually involve students to the system thinking approach that scientists use in order to produce pharmaceuticals. The transformation of natural products into pharmaceuticals is a multi- level procedure containing the knowledge of chemical properties and mechanisms, laboratory techniques for organic synthesis, monitoring reactions, purifications, identification of products, hazards, catalysts, alternative routes , yield, large scale synthesis and environmental impact.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License